Finotello, Riccardo 
ORCID: 0000-0002-1932-211X, Schiavo, Luca, Ressel, Lorenzo ORCID: 0000-0002-6614-1223, Frohmader, Ava, Silvestri, Paolo and Verin, Ranieri ORCID: 0000-0001-9366-5682
(2019)
Lipoxygenase-5 Expression in Canine Urinary Bladder: Normal Urothelium, Cystitis and Transitional Cell Carcinoma.
JOURNAL OF COMPARATIVE PATHOLOGY, 170.
pp. 1-9.
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Abstract
Transitional cell carcinoma (TCC) is the most common canine urinary tract tumour and mimics human invasive TCC. Human TCCs overexpress lipoxygenase (LOX)-5 and the use of target inhibitors has proven effective in inhibiting neoplastic growth. In this study, we investigated the immunohistochemical expression of LOX-5 in normal canine urinary bladder, cystitis and TCC. The comparative expression of LOX-5, cyclo-oxygenase (COX)-1 and COX-2 among the three tissue groups was also examined. Biopsy samples from cases of cystitis and TCC were reviewed from 2012 to 2016; samples of histologically normal bladder were used as controls. Dogs were excluded if they had received glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs) and/or chemotherapy prior to tissue collection. LOX-5 was expressed in 95% of TCCs, 23% of cases of cystitis and 10% of controls. LOX-5 and COX-2 immunohistochemistry scores were significantly (P <0.01) higher in TCCs versus cystitis and normal bladders. Results of this study support the rationale for further investigation of the use of NSAIDs with dual anti COX-2 and LOX-5 effect for the treatment of canine TCC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cystitis, dog, lipoxygenase, transitional cell carcinoma |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 11 Jun 2019 09:33 |
| Last Modified: | 19 Jan 2023 00:40 |
| DOI: | 10.1016/j.jcpa.2019.05.001 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3045275 |
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