Davies, Alys Elisabeth 
ORCID: 0000-0002-3489-0182
(2019)
In vitro and computational modelling of drug delivery in the eye for the treatment of retinal pathologies
PhD thesis, University of Liverpool.
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Abstract
Posterior segment diseases such as proliferative vitreoretinopathy and diabetic retinopathy have the potential to cause irreversible visual impairment. Delivery of therapeutic drugs to this region of the ocular globe poses many challenges owing to different anatomical and physiological constraints. There are some conditions that require drug treatment over prolonged periods of time and there is scope for the development of an extended drug delivery device to combat the burden of current treatment methods. Models can be a fast, inexpensive method of understanding the release profiles of therapeutics from such systems in an attempt to avoid toxic/ineffective treatment. Well designed, validated models could help speed the development of novel drug delivery systems and, if standardised, allow comparison between different technologies. Here the aim was to develop models of the drug clearance mechanisms in the posterior segment of the eye and test their ability to model drug transport behaviour from one potential drug delivery system. A static in vitro model of the outer blood retinal barrier (OBRB) was developed using a human retinal pigmented epithelium cell line, ARPE-19 cells, cultured on ammonium plasma treated ... (continues)
| Item Type: | Thesis (PhD) |
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| Divisions: | Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 15 Jul 2019 10:42 |
| Last Modified: | 02 Nov 2024 11:36 |
| DOI: | 10.17638/03046400 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3046400 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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