The Observed Effect of Gastric Bypass Surgery on Direct-acting Antiviral Treatment: a Case Report.

Smolders, Elise J, Willemse, Sophie B, El-Sherif, Omar, Khoo, Saye ORCID: 0000-0002-2769-0967 and Burger, David M
(2018) The Observed Effect of Gastric Bypass Surgery on Direct-acting Antiviral Treatment: a Case Report. Annals of hepatology, 17 (3). pp. 525-529.

Access the full-text of this item by clicking on the Open Access link.


Chronic hepatitis C virus (HCV) infection can be cured with treatment using direct-acting antivirals (DAAs). Although these drugs have been widely studied, information about certain special populations is missing. In this case report we describe a treatment-experienced patient with chronic HCV infection genotype 1b, treated with 150 mg/day simeprevir, 400 mg/day sofosbuvir, and 1,000 mg/ day ribavirin for 24 weeks, after a Roux-and-Y gastric bypass. At steady-state a pharmacokinetic curve was recorded of sofosbuvir, GS-331007, and simeprevir. Ribavirin trough plasma concentration (Ctrough) was determined. The simeprevir area under the-concentration time curve (AUClast) and Ctrough were 9.42 and 0.046 mg/L, respectively. Compared to what was described in the literature, simeprevir exposure was low and therefore the simeprevir dose was increased to 300 mg/day. The increased dose of simeprevir was well tolerated and Ctrough was 0.532 mg/L. Sofosbuvir AUClast and Ctrough were 0.63 and 0.0013 mg/L. GS-331007 AUClast and Ctrough were 21.02 and 0.35 mg/L. Ribavirin Ctrough was 2.5 mg/L. Sofosbuvir, GS-331007, and ribavirin exposure were comparable with levels described in literature. The patient achieved a sustained virological response twelve weeks after the completion of treatment.

Item Type: Article
Uncontrolled Keywords: Chronic hepatitis C virus infection, Direct-acting antivirals, Gastric bypass surgery, Pharmacokinetics, Simeprevir
Depositing User: Symplectic Admin
Date Deposited: 01 Aug 2019 15:36
Last Modified: 19 Jan 2023 00:36
DOI: 10.5604/01.3001.0011.7398
Open Access URL:
Related URLs: