Vrbica, Zarko, Labor, Marina, Koscec Duknic, Adrijana, Radosevic-Vidacek, Biserka, Gudelj, Ivan, Labor, Slavica, Juric, Iva, Calverley, Peter MA and Plavec, Davor
(2016)
Development and the initial validation of a new self-administered questionnaire for an early detection of health status changes in smokers at risk for chronic obstructive pulmonary disease (MARKO questionnaire).
CROATIAN MEDICAL JOURNAL, 57 (5).
pp. 425-433.
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Development and the initial validation of a new self-administered questionnaire for an early detection of health status changes in smokers at risk for chronic obstructive pulmonary disease (MARKO questionnaire).pdf - Published version Download (134kB) | Preview |
Abstract
<h4>Aim</h4>To develop and do an initial validation of a new simple tool (self-administered questionnaire) that would be sensitive and specific enough to detect early changes in smokers leading to future development of chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>224 consecutive participants (50.9% women), with mean±standard deviation age of 52.3±6.7 years, 37.5±16.7 pack-years smoking history (85.8% active smokers), and no prior diagnosis of COPD were recruited. The MARKO questionnaire was self-administered twice; at the general practitioner's office and after 2-4 weeks at the tertiary care hospital. Participants were assessed for COPD by a pulmonologist after filling in a quality of life (QoL) questionnaires, history-taking, physical examination, lung function test, 6-minute walk test, and laboratory tests. They were divided into four subgroups: "healthy" smokers, symptomatic smokers, and smokers with mild and moderately severe COPD.<h4>Results</h4>Psychometric analyses indicated that the 18-item questionnaire had a very good internal consistency (Cronbach's alpha=0.91) and test-retest reliability for a four week period (c=0.89, 95% confidence interval [CI] 0.85-0.92, Lin's concordance). A significant correlations of MARKO scores were found with two QoL questionnaires; r=0.69 (P<0.001) and r=0.81 (P<0.001). Receiver operating characteristic curve analysis showed an area under the curve of 0.753 (95% CI 0.691-0.808, <0.001), with a sensitivity of 71.83% and specificity of 64.24% to discriminate "healthy" smokers from other subgroups.<h4>Conclusion</h4>Based on psychometric analyses and high convergent validity correlation with already validated QoL questionnaires, the newly developed MARKO questionnaire was shown to be a reliable self-administered short health status assessment tool.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Pulmonary Disease, Chronic Obstructive, Early Diagnosis, Reproducibility of Results, ROC Curve, Smoking, Psychometrics, Health Status, Quality of Life, Aged, Middle Aged, Female, Male, Surveys and Questionnaires |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 08 Aug 2019 09:15 |
| Last Modified: | 19 Jan 2023 00:35 |
| DOI: | 10.3325/cmj.2016.57.425 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3051257 |
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