Serum biomarkers and outcomes in patients with moderate COPD: a substudy of the randomised SUMMIT trial



Celli, Bartolome R ORCID: 0000-0002-7266-8371, Anderson, Julie A, Brook, Robert, Calverley, Peter, Cowans, Nicholas J, Crim, Courtney, Dixon, Ian, Kim, Victor, Martinez, Fernando J, Morris, Andrea
et al (show 3 more authors) (2019) Serum biomarkers and outcomes in patients with moderate COPD: a substudy of the randomised SUMMIT trial. BMJ Open Respiratory Research, 6 (1). e000431 - e000431.

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Abstract

<jats:sec><jats:title>Rationale</jats:title><jats:p>Systemic levels of C reactive protein (CRP), surfactant protein D (SPD), fibrinogen, soluble receptor of activated glycogen end-product (sRAGE) and club cell protein 16 (CC-16) have been associated with chronic obstructive pulmonary disease (COPD) outcomes. However, they require validation in different cohorts.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>Relate systemic levels of those proteins to forced expiratory volume in 1 s (FEV<jats:sub>1</jats:sub>) decline, exacerbations, hospitalisations and mortality in COPD patients (FEV<jats:sub>1</jats:sub> of ≥50 and ≤70% predicted) and heightened cardiovascular risk in a substudy of the Study to Understand Mortality and MorbidITy trial.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Participants were randomised to daily inhalations of placebo, vilanterol 25 µg (VI), fluticasone furoate 100 µg (FF) or their combination (VI 25/FF 100) and followed quarterly until 1000 deaths in the overall 16 485 participants occurred. Biomarker blood samples were available from 1673 patients. The FEV<jats:sub>1</jats:sub> decline (mL/year), COPD exacerbations, hospitalisations and death were determined. Associations between biomarker levels and outcomes were adjusted by age and gender.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Systemic levels of CC-16, CRP, sRAGE, SPD and fibrinogen did not relate to baseline FEV<jats:sub>1</jats:sub>, FEV<jats:sub>1</jats:sub> decline, exacerbations or hospitalisations. Fibrinogen and CRP were related to mortality over a median follow-up of 2.3 years. Only the CC-16 changed with study therapy (VI, FF and FF/VI, p&lt;0.01) at 3 months.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In COPD, systemic levels of CC-16, CRP, sRAGE, SPD and fibrinogen were not associated with FEV<jats:sub>1</jats:sub> decline, exacerbations or hospitalisations. These results cast doubts about the clinical usefulness of the systemic levels of these proteins as surrogate markers of these COPD outcomes. The study confirms that CRP and fibrinogen are associated with increased risk of death in patients with COPD.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="clintrialgov" xlink:href="NCT01313676">NCT01313676</jats:ext-link>.</jats:p></jats:sec>

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 13 Aug 2019 09:12
Last Modified: 16 Sep 2020 07:18
DOI: 10.1136/bmjresp-2019-000431
URI: http://livrepository.liverpool.ac.uk/id/eprint/3051523