High-Intensity Interval Training Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People With Type 1 Diabetes

Scott, Sam N, Cocks, Matt, Andrews, Rob C, Narendran, Parth, Purewal, Tejpal S, Cuthbertson, Daniel J ORCID: 0000-0002-6128-0822, Wagenmakers, Anton JM and Shepherd, Sam O
(2018) High-Intensity Interval Training Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People With Type 1 Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 104 (2). pp. 604-612.

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<h4>Context</h4>We investigated whether 6 weeks of high-intensity interval training (HIT) induced improvements in cardiometabolic health markers similar to moderate-intensity continuous training (MICT) in people with type 1 diabetes (T1D), and whether HIT abolished acute reductions in plasma glucose levels observed after MICT sessions.<h4>Methods</h4>Two groups of sedentary individuals with T1D (n = 7 per group) completed 6 weeks of thrice weekly HIT or MICT. Pre- and post-training measurements were made of 24-hour interstitial glucose profiles, using continuous glucose monitors, and cardiometabolic health markers [peak oxygen consumption (V˙o2peak), blood lipid profile, and aortic pulse wave velocity (aPWV)]. Capillary blood glucose (BG) concentrations were assessed before and after exercise to investigate changes in BG levels during exercise in the fed state.<h4>Results</h4>Six weeks of HIT or MICT increased V˙o2peak by 14% and 15%, respectively (P < 0.001), and aPWV by 12% (P < 0.001), with no difference between groups. There was no difference in incidence or percentage of time spent in hypoglycemia after training in either group (P > 0.05). In the fed state, the mean change (±SEM) in capillary BG concentration during the HIT sessions was -0.2 ± 0.5 mmol/L, and -5.5 ± 0.4 mmol/L during MICT.<h4>Conclusions</h4>Six weeks of HIT improved V˙o2peak and aPWV to a similar extent as MICT. That BG levels remained stable during HIT in the fed state but consistently fell during MICT suggests HIT may be the preferred training mode for some people with T1D.

Item Type: Article
Uncontrolled Keywords: Humans, Cardiovascular Diseases, Diabetes Mellitus, Type 1, Blood Glucose, Treatment Outcome, Exercise Therapy, Fasting, Cross-Over Studies, Oxygen Consumption, Time Factors, Adult, Female, Male, Pulse Wave Analysis, High-Intensity Interval Training
Depositing User: Symplectic Admin
Date Deposited: 20 Aug 2019 09:03
Last Modified: 19 Jan 2023 00:28
DOI: 10.1210/jc.2018-01309
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3052194