Newman, DT 
ORCID: 0000-0003-0534-8914
(2019)
Investigating the composition of integrin adhesion complexes of cells cultured in 3-dimensional matrices.
PhD thesis, University of Liverpool.
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Abstract
Breast cancer is one of leading causes of cancer-related death in women. Triple negative breast cancer (TNBC) is characterised by the absence in expression of oestrogen and progesterone receptor and lack of HER2 overexpression. These are common therapy targets therefore treatment options for TNBC are limited. Metastasis, the escape of cells from the primary tumour and colonisation of secondary tumour sites, is the cause of the vast majority of solid tumour related mortalities. Cells are typically cultured and studied on 2D subtrates, however cells invading through 3D matrices, which is more typical of what might be encountered by an invading cell in vivo, will encounter different physio-chemical cues and barriers to cell migration. Very little is known about the nature of interaction sites that cells form with the extracellular matrix when cultured in a 3D microenvironment. This study aimed to determine how the composition of integrin-based adhesion complexes (IACs) formed by breast cancer cells cultured in a 3D microenvironment compared with those formed by cells cultured in 2D. With the goal of identifying functional modules that may be enriched or specific to a 3D microenvironment, for further investigation. ... (continues)
| Item Type: | Thesis (PhD) |
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| Divisions: | Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Dec 2019 14:28 |
| Last Modified: | 08 Feb 2025 16:37 |
| DOI: | 10.17638/03052432 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3052432 |
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