Premakumar, C 
ORCID: 0000-0001-6140-5069
(2019)
Optimisation of arginine intake in very preterm neonates on neonatal parenteral nutrition formulation.
PhD thesis, University of Liverpool.
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Abstract
The overall aim of the thesis was to design and test modified neonatal parenteral nutrition (PN) formulations with additional arginine content in very preterm neonates (VPNs) dependent on PN. Review of the literature resulted in a dose concentration graph that suggested a percentage content of about 14% and absolute arginine intake of about 600mg/kg/day to achieve target plasma arginine levels ≥80 micromoles/L. Previous studies have reported that VPNs dependent on PN have low plasma arginine levels and an oversupply of essential amino acids (EAAs). The difficulties with assessing amino acid (AA) status were explored using published AA profiles. Modified PN formulations using two different base AA solutions, Vaminolact® and Primene®, containing 14% arginine were designed and manufactured in an aseptic, clean room setting. These formulations were tested in a stability testing study using common physical tests such as visual appearance, pH, optical rotation, UV absorbance and sub-visible particle count. This thesis included AA assay of PN formulations as a part of PN stability testing. It was included to monitor the AA content in the PN formulations tested. The results showed that the modified PN formulations ... (continues)
| Item Type: | Thesis (PhD) |
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| Uncontrolled Keywords: | parenteral nutrition, neonate, premature, arginine |
| Divisions: | Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 10 Aug 2020 12:42 |
| Last Modified: | 01 Aug 2025 01:30 |
| DOI: | 10.17638/03055041 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3055041 |
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