Hill, Jonathan, Pickles, Andrew, Wright, Nicola 
ORCID: 0000-0002-3285-2051, Quinn, John P ORCID: 0000-0003-3551-7803, Murgatroyd, Chris and Sharp, Helen
(2019)
Mismatched Prenatal and Postnatal Maternal Depressive Symptoms and Child Behaviours: A Sex-Dependent Role for <i>NR3C1</i> DNA Methylation in the Wirral Child Health and Development Study.
CELLS, 8 (9).
E943-.
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Hill et al. mismatched prenatal and postnatal maternal depression and child behaviors.pdf - Author Accepted Manuscript Download (894kB) | Preview |
Abstract
Evolutionary hypotheses predict that male fetuses are more vulnerable to poor maternal conditions (Sex-biased Maternal Investment), but female fetuses are at greater risk of glucocorticoid-mediated disorders where there is a mismatch between fetal and postnatal environments (Predictive Adaptive Response). Self-reported prenatal and postnatal depression and maternal report of child anxious-depressed symptoms at 2.5, 3.5 and 5.0 years were obtained from an 'extensive' sample of first-time mothers (N = 794). Salivary <i>NR3C1</i> 1-F promoter methylation was assayed at 14 months in an 'intensive' subsample (n = 176) and stratified by psychosocial risk. Generalised structural equation models were fitted and estimated by maximum likelihood to allow the inclusion of participants from both intensive and extensive samples. Postnatal depression was associated with <i>NR3C1</i> methylation and anxious-depressed symptoms in daughters of mothers with low prenatal depression (prenatal-postnatal depression interaction for methylation, <i>p</i> < 0.001; for child symptoms, <i>p</i> = 0.011). In girls, <i>NR3C1</i> methylation mediated the association between maternal depression and child anxious-depressed symptoms. The effects were greater in girls than boys: the test of sex differences in the effect of the prenatal-postnatal depression interaction on both outcomes gave X<sup>2</sup> (2) = 5.95 (<i>p</i> = 0.051). This was the first human study to show that epigenetic and early behavioural outcomes may arise through different mechanisms in males and females.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | maternal depression, NR3C1 methylation, child anxiety-depression, sex differences, parental reproductive investment, epidemiological sampling, mediation, longitudinal design |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 19 Sep 2019 15:50 |
| Last Modified: | 05 Oct 2023 17:54 |
| DOI: | 10.3390/cells8090943 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3055221 |
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