Advancing Solutions to the Carbohydrate Sequencing Challenge

Gray, Christopher J, Migas, Lukasz G, Barran, Perdita E, Pagel, Kevin, Seeberger, Peter H, Eyers, Claire E ORCID: 0000-0002-3223-5926, Boons, Geert-Jan, Pohl, Nicola LB, Compagnon, Isabelle, Widmalm, Goran
et al (show 1 more authors) (2019) Advancing Solutions to the Carbohydrate Sequencing Challenge. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141 (37). pp. 14463-14479.

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Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function. Monosaccharide building blocks are defined by a high density of chiral centers. Additionally, the anomericity and regiochemistry of the glycosidic linkages carry important biological information. Any carbohydrate-sequencing method needs to be precise in determining all aspects of this stereodiversity. Recently, several advances have been made in developing fast and precise analytical techniques that have the potential to address the stereochemical complexity of carbohydrates. This perspective seeks to provide an overview of some of these emerging techniques, focusing on those that are based on NMR and MS-hybridized technologies including ion mobility spectrometry and IR spectroscopy.

Item Type: Article
Uncontrolled Keywords: Carbohydrates, Spectrum Analysis, Carbohydrate Sequence, Structure-Activity Relationship
Depositing User: Symplectic Admin
Date Deposited: 02 Dec 2019 09:38
Last Modified: 19 Jan 2023 00:25
DOI: 10.1021/jacs.9b06406
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