Critical considerations for targeting colorectal liver metastases with nanotechnology

Arshad, Usman ORCID: 0000-0003-1586-1885, Sutton, Paul A, Ashford, Marianne B, Treacher, Kevin E, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Rannard, Steve P ORCID: 0000-0002-6946-1097, Goldring, Christopher E and Owen, Andrew ORCID: 0000-0002-9819-7651 (2020) Critical considerations for targeting colorectal liver metastases with nanotechnology. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 12 (2). e1588-.

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Official URL: http://dx.doi.org/10.1002/wnan.1588

Abstract

Colorectal cancer remains a significant cause of morbidity and mortality worldwide. Half of all patients develop liver metastases, presenting unique challenges for their treatment. The shortcomings of conventional chemotherapy has encouraged the use of nanomedicines; the application of nanotechnology in the diagnosis and treatment of disease. In spite of technological improvements in nanotechnology, the complexity of biological systems hinders the prospect of nanomedicines being applied in cancer therapy at the present time. This review highlights current biological barriers and discusses aspects of tumor biology together with the physicochemical features of the nanocarrier, that need to be considered in order to develop effective nanotherapeutics for colorectal cancer patients with liver metastases. It becomes clear that incorporating an interdisciplinary approach when developing nanomedicines should assure appropriate disease-driven design and that this will form a critical step in improving their clinical translation. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

Item Type:	Article
Uncontrolled Keywords:	colorectal cancer, drug delivery, liver metastases, nanomedicines, tumor biology
Depositing User:	Symplectic Admin
Date Deposited:	03 Oct 2019 15:34
Last Modified:	19 Jan 2023 00:24
DOI:	10.1002/wnan.1588
Open Access URL:	https://doi.org/10.1002/wnan.1588
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3056923