Washbourn, GHM
(2019)
Synthesis, computational and biological evaluation of novel compounds for the treatment of Cryptococcus neoformans.
Doctor of Philosophy thesis, University of Liverpool.
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Abstract
Cryptococcus neoformans is a yeast like fungal pathogen that is relatively unknown despite causing large numbers of deaths per year. It is a disease that is prevalent in sub-Saharan Africa where the highest rate of deaths occur, at around 500,000 per year. It is particularly deadly in patients who are immunocompromised, such as those suffering from AIDS. This can lead to meningitis and encephalitis which often results in death. Current therapies are outdated and present with many issues surrounding their toxicity, efficacy and potential for resistance to emerge. C. neoformans as a pathogen is well adapted to the host environment, which means designing novel therapies is challenging. Recently, focus has turned to developing novel therapies that have new mechanisms of action compared to traditional C. neoformans treatments. The benzimidazoles, the initial and main focus of this project, were discovered when a small number of analogues were screened against clinical isolates of C. neoformans and some were found to possess excellent biological activity of 0.015 - >4 mg/L. This was coupled with in vivo work, demonstrating the commercially available anti-helminth drug flubendazole, possessed biological activity ... (continues)
| Item Type: | Thesis (Doctor of Philosophy) |
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| Divisions: | Faculty of Science and Engineering > School of Physical Sciences > Chemistry |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Aug 2020 09:39 |
| Last Modified: | 27 Oct 2024 15:03 |
| DOI: | 10.17638/03059421 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3059421 |
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