Deintensification of Adjuvant Treatment After Transoral Surgery in Patients With Human Papillomavirus-Positive Oropharyngeal Cancer: The Conception of the PATHOS Study and Its Development

Hargreaves, Sarah, Beasley, Matthew, Hurt, Chris, Jones, Terry M and Evans, Mererid (2019) Deintensification of Adjuvant Treatment After Transoral Surgery in Patients With Human Papillomavirus-Positive Oropharyngeal Cancer: The Conception of the PATHOS Study and Its Development. FRONTIERS IN ONCOLOGY, 9. 936-.

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Official URL: http://dx.doi.org/10.3389/fonc.2019.00936

Abstract

PATHOS is a phase II/III randomized controlled trial (RCT) of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery (TOS) for human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). The study opened in the UK in October 2015 and, after successful recruitment into the phase II, transitioned into phase III in the autumn of 2018. PATHOS aims to establish whether the de-intensification of adjuvant treatment in patients with favorable prognosis HPV-positive OPSCC will confer improved swallowing outcomes, whilst maintaining high rates of cure. In this article, we will outline the rationale for the study and how it aims to answer fundamentally important questions about the safety, effectiveness and functional outcomes of minimally invasive TOS techniques followed by adjuvant radiotherapy (RT) or chemo-radiotherapy (CRT) in this patient population.

Item Type:	Article
Uncontrolled Keywords:	HPV-related head and neck squamous cell carcinoma, PATHOS, deintensification, transoral surgery, adjuvant
Depositing User:	Symplectic Admin
Date Deposited:	04 Nov 2019 10:25
Last Modified:	19 Jan 2023 00:20
DOI:	10.3389/fonc.2019.00936
Open Access URL:	https://doi.org/10.3389/fonc.2019.00936
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3060513