Proteomic and transcriptomic investigation of the mechanisms and consequences of p53 gain of function mutation in laryngeal squamous cell carcinoma



Behrendt, Anna
(2011) Proteomic and transcriptomic investigation of the mechanisms and consequences of p53 gain of function mutation in laryngeal squamous cell carcinoma. European Archives of Otolaryngology, 267(su. 102-.

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Abstract

Loss of p53 function is a critical event in tumour development. It has been well documented that p53 mutation can lead to an oncogenic gain of function (GOF) associated with poorer prognosis and therapeutic response. Such mutants exert their gain-of-function properties by modifying cells through altered transcriptional activity as well as novel protein-protein interactions, but the molecular details of the mechanisms involved are still not entirely understood. Recent reports indicate that mutant p53 increases TGFβ-dependent metastatic potential of cancer cells via inhibition of p63 function and also promotes invasion through increased integrin (aSpl) and EGFR recycling, which is also linked with suppression of transcriptionally active p63 in normal epithelial cells, lung cancer cells and invasive breast cancer cells. The aim of this study was to investigate the mechanism of mutant p53 GOF in squamous cell carcinoma of the head and neck (SCCHN) cells. To avoid the potentially confounding impact of studying cells from biologically distinct anatomical sub-sites, the studies described here focused upon the most common sub-type of SCCHN -laryngeal squamous cell carcinoma (LSCC). Two hot-spot p53 mutants representing ... (continues)

Item Type: Article
Uncontrolled Keywords: Medicine, Oncology
Depositing User: Symplectic Admin
Date Deposited: 21 Nov 2019 13:59
Last Modified: 29 Oct 2024 18:07
DOI: 10.17638/03062692
URI: https://livrepository.liverpool.ac.uk/id/eprint/3062692