The Regulatory Role of MicroRNAs in Breast Cancer



Loh, Hui-Yi, Norman, Brendan P ORCID: 0000-0001-9293-4852, Lai, Kok-Song, Abd Rahman, Nik Mohd Afizan Nik, Alitheen, Noorjahan Banu Mohamed and Osman, Mohd Azuraidi
(2019) The Regulatory Role of MicroRNAs in Breast Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20 (19). E4940-.

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Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules which function as critical post-transcriptional gene regulators of various biological functions. Generally, miRNAs negatively regulate gene expression by binding to their selective messenger RNAs (mRNAs), thereby leading to either mRNA degradation or translational repression, depending on the degree of complementarity with target mRNA sequences. Aberrant expression of these miRNAs has been linked etiologically with various human diseases including breast cancer. Different cellular pathways of breast cancer development such as cell proliferation, apoptotic response, metastasis, cancer recurrence and chemoresistance are regulated by either the oncogenic miRNA (oncomiR) or tumor suppressor miRNA (tsmiR). In this review, we highlight the current state of research into miRNA involved in breast cancer, with particular attention to articles published between the years 2000 to 2019, using detailed searches of the databases PubMed, Google Scholar, and Scopus. The post-transcriptional gene regulatory roles of various dysregulated miRNAs in breast cancer and their potential as therapeutic targets are also discussed.

Item Type: Article
Uncontrolled Keywords: microRNAs, breast cancer, oncomiR, tsmiR
Depositing User: Symplectic Admin
Date Deposited: 22 Nov 2019 09:04
Last Modified: 19 Jan 2023 00:19
DOI: 10.3390/ijms20194940
Open Access URL: https://doi.org/10.3390/ijms20194940
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3063023