Outcomes of hepatocellular carcinoma patients treated with sorafenib: a meta-analysis of Phase III trials



Cabibbo, Giuseppe, Cucchetti, Alessandro, Cammà, Calogero, Casadei-Gardini, Andrea, Celsa, Ciro, Emanuele Maria Rizzo, Giacomo, Johnson, Philip ORCID: 0000-0003-1404-0209 and Ercolani, Giorgio
(2019) Outcomes of hepatocellular carcinoma patients treated with sorafenib: a meta-analysis of Phase III trials. Future Oncology, 15 (29). 3411 - 3422.

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Abstract

Aim: To benchmark overall survival (OS) and time to radiological progression (TTP) of patients enrolled in randomized controlled trials (RCTs) assessing sorafenib in advanced hepatocellular carcinoma using individual participant survival data, and to meta-analyze prognostic factors for OS and TTP. Methods: RCTs were identified through literature search until December 2018. Individual participant survival was reconstructed with an algorithm from published Kaplan-Meier curves. Results: Ten RCTs were included. Median OS was 10.0 months (95% CI: 9.6-10.5), and median TTP was 4.1 months (95% CI: 3.8-4.3). Multivariable analyses showed HCV positivity, absence of macrovascular invasion and extra-hepatic disease as predictors of longer OS. Conclusion: We provided a benchmark for future studies on sorafenib. The present results can be used in the decision making for the early shift to second-line strategy.

Item Type: Article
Uncontrolled Keywords: hepatocellular carcinoma, meta-regression, sorafenib, survival, systemic therapy, time to progression
Depositing User: Symplectic Admin
Date Deposited: 26 Nov 2019 16:54
Last Modified: 09 Sep 2022 07:31
DOI: 10.2217/fon-2019-0287
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3063566