Qvist, Tavs, Schlüter, Daniela K, Rajabzadeh, Vian, Diggle, Peter, Pressler, Tania, Carr, Siobhan and Taylor-Robinson, DC ORCID: 0000-0002-5828-7724
(2019)
Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations.
Journal of Cystic Fibrosis, 18 (3).
pp. 390-395.
This is the latest version of this item.
Text
1-s2.0-S1569199318308580-main.pdf - Published version Available under License : See the attached licence file. Download (540kB) |
Abstract
Background Many risk factors for lung disease in cystic fibrosis (CF) display a seasonal pattern yet it is unclear whether this is reflected in seasonal fluctuations in lung function. Methods We conducted a longitudinal study using CF registries in Denmark and the UK. 471 individuals with a median of 104 FEV1 measurements per person and 7586 individuals with a median of nine FEV1 measures per person were included from Denmark and the UK respectively. We estimated the effect of seasonality on percent predicted FEV1 trajectories using mixed effects models whilst adjusting for clinically important covariates. Results We found no significant cyclical seasonal variation in lung function in either country. The maximum variation in percent predicted FEV1 around the yearly average was estimated to be 0.1 percentage points (95%CI 0 to 0.21) and 0.14 percentage points (95%CI 0 to 0.29) in Denmark and the UK, respectively. When considering possible step-like changes between the four seasons, we found that lung function was higher in spring compared to winter in the UK (0.34 percentage points, 95%CI 0.1 to 0.59) though the difference was not of clinical significance. Conclusion In both the UK and Denmark there may be small seasonal changes in lung function but this effect is not of clinical importance
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Seasonality, Season, Fluctuation, Percent predicted FEV1 |
Depositing User: | Symplectic Admin |
Date Deposited: | 04 Dec 2019 08:54 |
Last Modified: | 19 Jan 2023 00:18 |
DOI: | 10.1016/j.jcf.2018.10.006 |
Open Access URL: | https://www.cysticfibrosisjournal.com/article/S156... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3063700 |
Available Versions of this Item
-
Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations. (deposited 22 Oct 2018 09:28)
- Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations. (deposited 04 Dec 2019 08:54) [Currently Displayed]