Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations



Qvist, Tavs, Schlüter, Daniela K, Rajabzadeh, Vian, Diggle, Peter, Pressler, Tania, Carr, Siobhan and Taylor-Robinson, DC ORCID: 0000-0002-5828-7724
(2019) Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations. Journal of Cystic Fibrosis, 18 (3). 390 - 395.

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Abstract

Background Many risk factors for lung disease in cystic fibrosis (CF) display a seasonal pattern yet it is unclear whether this is reflected in seasonal fluctuations in lung function. Methods We conducted a longitudinal study using CF registries in Denmark and the UK. 471 individuals with a median of 104 FEV1 measurements per person and 7586 individuals with a median of nine FEV1 measures per person were included from Denmark and the UK respectively. We estimated the effect of seasonality on percent predicted FEV1 trajectories using mixed effects models whilst adjusting for clinically important covariates. Results We found no significant cyclical seasonal variation in lung function in either country. The maximum variation in percent predicted FEV1 around the yearly average was estimated to be 0.1 percentage points (95%CI 0 to 0.21) and 0.14 percentage points (95%CI 0 to 0.29) in Denmark and the UK, respectively. When considering possible step-like changes between the four seasons, we found that lung function was higher in spring compared to winter in the UK (0.34 percentage points, 95%CI 0.1 to 0.59) though the difference was not of clinical significance. Conclusion In both the UK and Denmark there may be small seasonal changes in lung function but this effect is not of clinical importance

Item Type: Article
Uncontrolled Keywords: Seasonality, Season, Fluctuation, Percent predicted FEV1
Depositing User: Symplectic Admin
Date Deposited: 04 Dec 2019 08:54
Last Modified: 13 Aug 2022 12:02
DOI: 10.1016/j.jcf.2018.10.006
Open Access URL: https://www.cysticfibrosisjournal.com/article/S156...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3063700

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