Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty

Rattray, Nicholas JW, Trivedi, Drupad K, Xu, Yun ORCID: 0000-0003-3228-5111, Chandola, Tarani, Johnson, Caroline H, Marshall, Alan D, Mekli, Krisztina, Rattray, Zahra, Tampubolon, Gindo, Vanhoutte, Bram ORCID: 0000-0002-8032-9214
et al (show 5 more authors) (2019) Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty. NATURE COMMUNICATIONS, 10 (1). 5027-.

Access the full-text of this item by clicking on the Open Access link.
[img] Text
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty.pdf - Published version

Download (2MB) | Preview


Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in poor health in later life. In this study, we present a population level assessment of the metabolic phenotype associated with frailty. Analysis of serum from 1191 older individuals (aged between 56 and 84 years old) and subsequent longitudinal validation (on 786 subjects) was carried out using liquid and gas chromatography-mass spectrometry metabolomics and stratified across a frailty index designed to quantitatively summarize vulnerability. Through multivariate regression and network modelling and mROC modeling we identified 12 significant metabolites (including three tocotrienols and six carnitines) that differentiate frail and non-frail phenotypes. Our study provides evidence that the dysregulation of carnitine shuttle and vitamin E pathways play a role in the risk of frailty.

Item Type: Article
Uncontrolled Keywords: Humans, Vitamin E, Carnitine, Discriminant Analysis, Reproducibility of Results, Energy Metabolism, Aging, Phenotype, Principal Component Analysis, Aged, Middle Aged, Female, Male, Metabolic Networks and Pathways, Frailty, Confounding Factors, Epidemiologic
Depositing User: Symplectic Admin
Date Deposited: 28 Nov 2019 15:02
Last Modified: 19 Jan 2023 00:18
DOI: 10.1038/s41467-019-12716-2
Open Access URL:
Related URLs: