Global Review of the Age Distribution of Rotavirus Disease in Children Aged < 5 Years Before the Introduction of Rotavirus Vaccination



Hasso-Agopsowicz, Mateusz, Ladva, Chandresh Nanji, Lopman, Benjamin, Sanderson, Colin, Cohen, Adam L, Tate, Jacqueline E, Riveros, Ximena, Henao-Restrepo, Ana Maria, Clark, Andrew, Alkorta, M
et al (show 126 more authors) (2019) Global Review of the Age Distribution of Rotavirus Disease in Children Aged < 5 Years Before the Introduction of Rotavirus Vaccination. CLINICAL INFECTIOUS DISEASES, 69 (6). pp. 1071-1078.

Access the full-text of this item by clicking on the Open Access link.

Abstract

We sought datasets with granular age distributions of rotavirus-positive disease presentations among children <5 years of age, before the introduction of rotavirus vaccines. We identified 117 datasets and fit parametric age distributions to each country dataset and mortality stratum. We calculated the median age and the cumulative proportion of rotavirus gastroenteritis events expected to occur at ages between birth and 5.0 years. The median age of rotavirus-positive hospital admissions was 38 weeks (interquartile range [IQR], 25-58 weeks) in countries with very high child mortality and 65 weeks (IQR, 40-107 weeks) in countries with very low or low child mortality. In countries with very high child mortality, 69% of rotavirus-positive admissions in children <5 years of age were in the first year of life, with 3% by 10 weeks, 8% by 15 weeks, and 27% by 26 weeks. This information is critical for assessing the potential benefits of alternative rotavirus vaccination schedules in different countries and for monitoring program impact.

Item Type: Article
Uncontrolled Keywords: vaccine, rotavirus, rotavirus gastroenteritis, age distribution
Depositing User: Symplectic Admin
Date Deposited: 29 Nov 2019 09:39
Last Modified: 19 Jan 2023 00:18
DOI: 10.1093/cid/ciz060
Open Access URL: https://doi.org/10.1093/cid/ciz060
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3063988