Effects of pentoxifylline on inflammatory markers and blood pressure: a systematic review and meta-analysis of randomized controlled trials



Brie, Daniel, Sahebkar, Amirhossein, Penson, Peter E ORCID: 0000-0001-6763-1489, Dinca, Madalina, Ursoniu, Sorin, Serban, Maria-Corina, Zanchetti, Alberto, Howard, George, Ahmed, Ali, Aronow, Wilbert S
et al (show 5 more authors) (2016) Effects of pentoxifylline on inflammatory markers and blood pressure: a systematic review and meta-analysis of randomized controlled trials. JOURNAL OF HYPERTENSION, 34 (12). pp. 2318-2329.

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Abstract

<h4>Introduction</h4>Pentoxifylline is a xanthine derivative with potential cardiovascular benefits.<h4>Aim</h4>To evaluate the impact of pentoxifylline on blood pressure (BP) and plasma TNF-α, C-reactive protein (CRP) and IL-6 through a systematic review and meta-analysis of randomized controlled trials.<h4>Methods</h4>The protocol was registered (PROSPERO: CRD42016035988). The search included PUBMED, ProQuest, Scopus and EMBASE until 1 September 2015 to identify trials reporting BP or inflammatory markers during pentoxifylline therapy. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WDF) and 95% confidence intervals (CIs) as summary statistics.<h4>Results</h4>Fifteen studies (16 treatment arms) were found to be eligible for inclusion. Meta-analysis did not suggest any effect of pentoxifylline on either SBP or DBP. Pentoxifylline treatment was associated with a significant reduction in plasma concentrations of TNF-α (WDF: -1.03 pg/ml, 95% CI: -1.54, -0.51; P < 0.001, 11 treatment arms) and CRP (WDF: -1.39 mg/l, 95% CI: -2.68, -0.10; P = 0.034, five treatment arms). No alteration in plasma IL-6 concentration was observed. The impact of pentoxifylline on plasma TNF-α levels was found to be positively associated with treatment duration (slope: 0.031; 95% CI: 0.004, 0.057; P = 0.023) but independent of pentoxifylline dose (slope: -0.0003; 95% CI: -0.002, 0.001; P = 0.687).<h4>Conclusion</h4>Pentoxifylline did not alter BP or plasma IL-6 concentration, but significantly reduced circulating TNF-α and CRP concentrations.

Item Type: Article
Uncontrolled Keywords: blood pressure, C-reactive protein, IL-6, pentoxifylline, TNF-alpha
Depositing User: Symplectic Admin
Date Deposited: 03 Dec 2019 09:37
Last Modified: 27 Apr 2023 22:00
DOI: 10.1097/HJH.0000000000001086
Open Access URL: http://researchonline.ljmu.ac.uk/id/eprint/3945/
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3064578