Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women



Lum, Fok-Moon, Narang, Vipin, Hue, Susan, Chen, Jie, McGovern, Naomi, Rajarethinam, Ravisankar, Tan, Jeslin JL, Amrun, Siti Naqiah, Chan, Yi-Hao, Lee, Cheryl YP
et al (show 12 more authors) (2019) Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women. Clinical and Translational Immunology, 8 (11).

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Abstract

Objectives Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear. Methods Full‐term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis. Results In this study, each woman exhibited a unique immune response with raised IL‐1RA, IP‐10, EGF and RANTES expression and neutrophil numbers during the acute infection phase. Although ZIKV NS3 antigens co‐localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential eIF2 signalling, mitochondrial dysfunction and oxidative phosphorylation. Despite these, the babies were delivered without any congenital anomalies. Conclusion These findings should translate to improve clinical prenatal screening procedures for virus‐infected pregnant patients.

Item Type: Article
Uncontrolled Keywords: histology, infection, placenta, RNA-seq, transcriptomics, Zika virus
Depositing User: Symplectic Admin
Date Deposited: 09 Dec 2019 10:39
Last Modified: 14 Sep 2022 18:10
DOI: 10.1002/cti2.1082
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3064945