Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations



Hobson, James J ORCID: 0000-0003-2551-1774, Curley, Paul ORCID: 0000-0003-4596-2708, Savage, Alison C ORCID: 0000-0002-5312-9946, Al-khouja, Amer, Siccardi, Marco ORCID: 0000-0002-3539-7867, Flexner, Charles, Meyers, Caren Freel, Owen, Andrew ORCID: 0000-0002-9819-7651 and Rannard, Steve P
(2019) Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations. Nanoscale Advances, 1 (11). 4301 - 4307.

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Abstract

<p>The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.</p>

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 06 Dec 2019 11:21
Last Modified: 17 Jun 2020 07:10
DOI: 10.1039/c9na00529c
Open Access URL: https://doi.org/10.1039/C9NA00529C
URI: http://livrepository.liverpool.ac.uk/id/eprint/3065165