Roles of galectin-3 in metabolic disorders and tumor cell metabolism

Li, Ying-Shuang, Li, Xiao-Tong, Yu, Lu-Gang ORCID: 0000-0001-9641-3712, Wang, Lei, Shi, Zhao-Yu and Guo, Xiu-Li (2020) Roles of galectin-3 in metabolic disorders and tumor cell metabolism. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 142. pp. 463-473.

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Official URL: http://dx.doi.org/10.1016/j.ijbiomac.2019.09.118

Abstract

The galactoside-binding protein galectin-3 is commonly overexpressed by cancer cells and promotes cancer progression and metastasis. Over the past few years, evidence has emerged that galectin-3 is also overexpressed in several metabolic malfunction conditions such as diabetes, obesity and atherosclerosis and is involved in the regulation of the occurrence and development of these diseases. Recently, Galectin-3 expression is shown also to be associated with glycolysis and mitochondrial metabolism in tumors, and promotes tumor metabolic reprogramming for their adaption to the microenvironment stress imposed by oxygen and nutrients deprivation. This brief review summarizes the current understanding of the roles and actions of galectin-3 in these metabolic diseases and in tumor metabolism.

Item Type:	Article
Uncontrolled Keywords:	Galectin-3, Metabolic disorders, Tumor metabolism
Depositing User:	Symplectic Admin
Date Deposited:	10 Dec 2019 10:26
Last Modified:	19 Jan 2023 00:13
DOI:	10.1016/j.ijbiomac.2019.09.118
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3065587