Ali, Monadil H, Alrasheedy, Alian A, Kibuule, Dan ORCID: 0000-0002-6908-2177, Hassali, Mohamed Azmi, Godman, Brian
ORCID: 0000-0001-6539-6972, Abdelwahab, Mohammed F and Abbadi, Raef Y
(2019)
Isoniazid acetylation phenotypes in the Sudanese population; findings and implications.
Journal of clinical tuberculosis and other mycobacterial diseases, 17.
100120-.
![]() |
Text
Ali et al - accepted for publication.docx - Author Accepted Manuscript Download (295kB) |
Abstract
<h4>Background</h4>Isoniazid (INH) is the mainstay antimicrobial in the treatment of tuberculosis (TB). It is acetlylated in the liver to acetyl-INH. However, there is variation in rate of acetylation of INH among TB patients (i.e. fast, intermediate or slow acetylators) which impacts on the treatment outcomes.<h4>Aim</h4>The isoniazid acetylation phenotypes in the expatriate Sudanese population were determined to provide future guidance since TB is prevalent in Sudan.<h4>Methods</h4>A community-based trial among Sudanese expatriates in Saudi Arabia was undertaken to identify INH-acetylation phenotypes. After overnight fasting, a single dose of 200 mg of INH was given to the volunteers. Three hours later, 5 ml of blood were drawn from each volunteer and prepared for High-Performance Liquid Chromatography (HPLC) analysis. The main outcomes were INH and Acetyl-INH concentrations in plasma and the subsequent Acetyl-INH/INH metabolic ratio (MR).<h4>Results</h4>The findings suggest that slow acetylation is highly prevalent among the study participants (<i>n</i> = 43; 84.31%). Moreover, there was no statistically significant correlation between age and the MR (<i>r</i> = -0.18, <i>P</i> = 0.20). Further, there was no significant association between gender and the MR (<i>P</i> = 0.124). Similarly, no significant association was found between smoking habits and MR (<i>P</i> = 0.24).<h4>Conclusion</h4>Isoniazid phenotyping suggests predominantly slow acetylation among the Sudanese in this sample. The study found no statistically significant associations between the MR and age or gender or smoking.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Acetylation, Fast acetylators, INH, Isoniazid, Slow acetylators, Sudanese populations, Tuberculosis |
Depositing User: | Symplectic Admin |
Date Deposited: | 10 Dec 2019 09:06 |
Last Modified: | 19 Jan 2023 00:13 |
DOI: | 10.1016/j.jctube.2019.100120 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3065667 |