Diener, Hans-Christoph, Hart, Robert G, Koudstaal, Peter J, Lane, Deirdre A 
ORCID: 0000-0002-5604-9378 and Lip, Gregory YH ORCID: 0000-0002-7566-1626
(2019)
Atrial Fibrillation and Cognitive Function <i>JACC</i> Review Topic of the Week.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 73 (5).
pp. 612-619.
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Abstract
Numerous vascular risk factors and vascular diseases contribute to cognitive impairment and dementia. Many studies and registries show an association of atrial fibrillation (AF) with cognitive impairment, cognitive decline, and dementia. This is true for vascular dementia and Alzheimer's disease. The assumed multifactorial mechanisms include ischemic stroke, both apparent and silent, cerebral microinfarcts, cerebral hemorrhage, and reduced cerebral blood flow. A number of retrospective observational and prospective studies support that anticoagulation in patients with AF may reduce the risk of cognitive decline and dementia. This holds for both vitamin K antagonists (e.g., warfarin) and direct oral anticoagulants. However, it still remains unproven if anticoagulation reduces cognitive decline and dementia in AF patients based on randomized trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anticoagulation, atrial fibrillation, cognitive impairment, dementia |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 16 Dec 2019 08:55 |
| Last Modified: | 12 Oct 2023 17:58 |
| DOI: | 10.1016/j.jacc.2018.10.077 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3066269 |
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