Duration and Density of Fecal Rotavirus Shedding in Vaccinated Malawian Children With Rotavirus Gastroenteritis



Bennett, Aisleen, Pollock, Louisa, Jere, Khuzwayo C ORCID: 0000-0003-3376-8529, Pitzer, Virginia E, Lopman, Benjamin, Bar-Zeev, Naor, Iturriza-Gomara, Miren ORCID: 0000-0001-5816-6423 and Cunliffe, Nigel A ORCID: 0000-0002-5449-4988
(2019) Duration and Density of Fecal Rotavirus Shedding in Vaccinated Malawian Children With Rotavirus Gastroenteritis. The Journal of Infectious Diseases, 222 (12). 2035 - 2040.

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Abstract

Quantifying rotavirus shedding among vaccinated individuals will aid understanding of vaccine indirect effects. Serial stool samples were collected from 196 children who presented with rotavirus gastroenteritis to health facilities in Blantyre, Malawi, and were tested for rotavirus using a VP6 semi-quantitative, real-time polymerase chain reaction. The median duration of fecal shedding was 28 days (95% CI, 19-28). The median copy numbers for peak shedding were 1.99 × 107 (interquartile range, 3.39 × 106 to 6.37 × 107). The fecal viral load was positively associated with disease severity and negatively associated with serum anti-rotavirus immunoglobin A. High and persistent rotavirus shedding among vaccinated children with breakthrough disease may contribute to ongoing transmission in this setting.

Item Type: Article
Uncontrolled Keywords: rotavirus, transmission, vaccine effectiveness, shedding
Depositing User: Symplectic Admin
Date Deposited: 17 Dec 2019 13:25
Last Modified: 25 Jan 2022 18:27
DOI: 10.1093/infdis/jiz612
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3066811