Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models



Weaver, Richard J, Blomme, Eric A, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Copple, Ian M ORCID: 0000-0003-4101-1913, Gerets, Helga HJ, Goldring, Christopher E, Guillouzo, Andre, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig
et al (show 12 more authors) (2020) Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19 (2). 131 - 148.

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Abstract

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of human DILI thus remain inadequate. A systematic and concerted research effort is required to address the deficiencies in current models and to present a defined approach towards the development of new or adapted model systems for DILI prediction. This Perspective defines the current status of available models and the mechanistic understanding of DILI, and proposes our vision of a roadmap for the development of predictive preclinical models of human DILI.

Item Type: Article
Uncontrolled Keywords: adverse effects, drug discovery, preclinical research
Depositing User: Symplectic Admin
Date Deposited: 20 Dec 2019 15:01
Last Modified: 15 Jan 2021 20:11
DOI: 10.1038/s41573-019-0048-x
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3067231