Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR

Rolt, Adam, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Liang, T Jake and Stachulski, Andrew V (2019) Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR. RSC ADVANCES, 9 (69). pp. 40336-40339. ISSN 2046-2069, 2046-2069

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Official URL: https://doi.org/10.1039/c9ra08256e

Abstract

The unusual α-amino, β-hydroxy acid MeBmt is a key structural feature of cyclosporin A, an important naturally occurring immunosuppressant and antiviral agent. We present a convergent synthesis of MeBmt which relies on new aspects of dynamic kinetic resolution (DKR) to establish simultaneously the chirality at C(2) and C(3). We also show that this route is applicable to the synthesis of other derivatives.

Item Type:	Article
Uncontrolled Keywords:	3405 Organic Chemistry, 34 Chemical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	13 Jan 2020 10:59
Last Modified:	07 Dec 2024 19:12
DOI:	10.1039/c9ra08256e
Open Access URL:	https://doi.org/10.1039/C9RA08256E
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3070451