Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR

Rolt, Adam, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Liang, T Jake and Stachulski, Andrew V (2019) Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR. RSC ADVANCES, 9 (69). pp. 40336-40339.

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Official URL: http://dx.doi.org/10.1039/c9ra08256e

Abstract

The unusual α-amino, β-hydroxy acid MeBmt is a key structural feature of cyclosporin A, an important naturally occurring immunosuppressant and antiviral agent. We present a convergent synthesis of MeBmt which relies on new aspects of dynamic kinetic resolution (DKR) to establish simultaneously the chirality at C(2) and C(3). We also show that this route is applicable to the synthesis of other derivatives.

Item Type:	Article
Depositing User:	Symplectic Admin
Date Deposited:	13 Jan 2020 10:59
Last Modified:	19 Jan 2023 00:10
DOI:	10.1039/c9ra08256e
Open Access URL:	https://doi.org/10.1039/C9RA08256E
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3070451