Cauda Equina Syndrome Core Outcome Set (CESCOS): An international patient and healthcare professional consensus for research studies

Srikandarajah, Nisaharan, Noble, Adam ORCID: 0000-0002-8070-4352, Clark, Simon, Wilby, Martin, Freeman, Brian JC, Fehlings, Michael G, Williamson, Paula R ORCID: 0000-0001-9802-6636 and Marson, Tony ORCID: 0000-0002-6861-8806
(2020) Cauda Equina Syndrome Core Outcome Set (CESCOS): An international patient and healthcare professional consensus for research studies. PLOS ONE, 15 (1). e0225907-e0225907.

This is the latest version of this item.

Access the full-text of this item by clicking on the Open Access link.
[img] Text
Srikandarajah et al 20_PLOS One.docx - Author Accepted Manuscript

Download (76kB)
[img] Text
journal.pone.0225907.pdf - Published version

Download (629kB) | Preview


<h4>Background</h4>Cauda Equina Syndrome (CES) is an emergency condition that requires acute intervention and can lead to permanent neurological deficit in working age adults. A Core Outcome Set (COS) is the minimum set of outcomes that should be reported by a research study within a specific disease area. There is significant heterogeneity in outcome reporting for CES, which does not allow data synthesis between studies. The hypothesis is that a COS for CES can be developed for future research studies using patients and healthcare professionals (HCPs) as key stakeholders.<h4>Methods and findings</h4>Qualitative semi-structured interviews with CES patients were audio-recorded, transcribed and analysed using NVivo to identify the outcomes of importance. These were combined with the outcomes obtained from a published systematic literature review of CES patients. The outcomes were grouped into a list of 37, for rating through two rounds of an international Delphi survey according to pre-set criteria. The Delphi survey had an overall response rate of 63% and included 172 participants (104 patients, 68 HCPs) from 14 countries who completed both rounds. Thirteen outcomes reached consensus at the end of the Delphi survey and there was no attrition bias detected. The results were discussed at an international consensus meeting attended by 34 key stakeholders (16 patients and 18 HCPs) from 8 countries. A further three outcomes were agreed to be included. There was no selection bias detected at the consensus meeting. There are 16 outcomes in total in the CESCOS.<h4>Discussion</h4>This is the first study in the literature that has determined the core outcomes in CES using a transparent international consensus process involving healthcare professionals and CES patients as key stakeholders. This COS is recommended as the most important outcomes to be reported in any research study investigating CES outcomes and will allow evidence synthesis in CES.

Item Type: Article
Uncontrolled Keywords: Humans, Registries, Consensus, Quality of Life, Delphi Technique, Adolescent, Adult, Aged, Middle Aged, Health Personnel, Patients, Female, Male, Urinary Bladder, Interviews as Topic, Young Adult, Stakeholder Participation, Cauda Equina Syndrome, Outcome Assessment, Health Care
Depositing User: Symplectic Admin
Date Deposited: 28 Jan 2020 10:36
Last Modified: 27 Jan 2024 02:58
DOI: 10.1371/journal.pone.0225907
Open Access URL:
Related URLs:

Available Versions of this Item