Spinal signalling of C-fiber mediated pleasant touch in humans.

Marshall, Andrew G ORCID: 0000-0001-8273-7089, Sharma, Manohar L, Marley, Kate, Olausson, Hakan and McGlone, Francis P (2019) Spinal signalling of C-fiber mediated pleasant touch in humans. eLife, 8. e51642-. ISSN 2050-084X, 2050-084X

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Abstract

C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integrated hedonic and discriminative spinal processing from the body.

Item Type:	Article
Uncontrolled Keywords:	Spinothalamic Tracts, Afferent Pathways, Nerve Fibers, Unmyelinated, Mechanoreceptors, Skin, Humans, Pruritus, Cordotomy, Physical Stimulation, Emotions, Touch, Pleasure-Pain Principle, Aged, Middle Aged, Female, Male, Touch Perception, Pleasure
Depositing User:	Symplectic Admin
Date Deposited:	10 Feb 2020 16:05
Last Modified:	22 May 2026 20:29
DOI:	10.7554/eLife.51642
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3074402
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