Microvesicles in vascular homeostasis and diseases Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology



Ridger, Victoria C, Boulanger, Chantal M, Angelillo-Scherrer, Anne, Badimon, Lina, Blanc-Brude, Olivier, Bochaton-Piallat, Marie-Luce, Boilard, Eric, Buzas, Edit I, Caporali, Andreas, Dignat-George, Francoise
et al (show 15 more authors) (2017) Microvesicles in vascular homeostasis and diseases Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. THROMBOSIS AND HAEMOSTASIS, 117 (7). pp. 1296-1316.

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Abstract

Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as "microparticles". There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.

Item Type: Article
Uncontrolled Keywords: Atherothrombosis, cell-cell interactions, inflammatory mediators, macrophage
Depositing User: Symplectic Admin
Date Deposited: 13 Feb 2020 15:28
Last Modified: 19 Jan 2023 00:03
DOI: 10.1160/TH16-12-0943
Open Access URL: http://eprints.whiterose.ac.uk/117711/3/Revised%20...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3074876