Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders

Shirazi-Beechey, Soraya (2020) Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders. Journal of Agricultural and Food Chemistry, 68 (2). pp. 441-450.

	Text moran et al 2019 acs.pdf - Author Accepted Manuscript Available under License : See the attached licence file. Download (905kB) | Preview
	Text Moran et al 2019 JAFC.pdf - Submitted version Available under License : See the attached licence file. Download (3MB)
	Text Consumption.pdf - Published version Available under License : See the attached licence file. Download (3MB) | Preview

Abstract

Absorption of glucose, via intestinal Na⁺/glucose cotransporter 1 (SGLT1), activates salt and water absorption and is an effective route for treating <i>Escherichia coli</i> (<i>E. coli</i>)-induced diarrhea. Activity and expression of SGLT1 is regulated by sensing of sugars and artificial/natural sweeteners by the intestinal sweet receptor T1R2-T1R3 expressed in enteroendocrine cells. Diarrhea, caused by the bacterial pathogen <i>E. coli</i>, is the most common post-weaning clinical feature in rabbits, leading to mortality. We demonstrate here that, in rabbits with experimentally <i>E. coli</i>-induced diarrhea, inclusion of a supplement containing stevia leaf extract (SL) in the feed decreases cumulative morbidity, improving clinical signs of disease (<i>p</i> < 0.01). We show that the rabbit intestine expresses T1R2-T1R3. Furthermore, intake of SL enhances activity and expression of SGLT1 and the intestinal capacity to absorb glucose (1.8-fold increase, <i>p</i> < 0.05). Thus, a natural plant extract sweetener can act as an effective feed additive for lessening the negative impact of enteric diseases in animals.

Item Type:	Article
Uncontrolled Keywords:	colibacillosis, oral rehydration, rabbit, SGLT1, intestinal T1R2-T1R3
Depositing User:	Symplectic Admin
Date Deposited:	02 Jul 2020 08:48
Last Modified:	19 Jan 2023 00:02
DOI:	10.1021/acs.jafc.9b04995
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3075587

Available Versions of this Item

• Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders. (deposited 11 Nov 2019 16:08)
  • Consumption of a natural high intensity sweetener enhances activity and expression of rabbit intestinal Na+-glucose cotransporter 1 (SGLT1) and improves colibacillosis- induced enteric disorders. (deposited 18 Feb 2020 10:08)
    • Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders. (deposited 02 Jul 2020 08:48) [Currently Displayed]