Development and validation of a rapid, generic measure of disease control from the patient's perspective: The IBD-Control questionnaire

Bodger, K ORCID: 0000-0002-1825-3239, Ormerod, C, Shackcloth, D, Harrison, M and Collaborative, IBD Control (2014) Development and validation of a rapid, generic measure of disease control from the patient's perspective: The IBD-Control questionnaire. Gut, 63 (7). pp. 1092-1102.

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Official URL: https://gut.bmj.com/content/63/7/1092

Abstract

Introduction: The use of patient reported outcome measures to support routine inflammatory bowel disease (IBD) care is not widespread and suggests that existing questionnaires lack relevance to day-to-day decisions or are too cumbersome to administer. We developed a simple, generic tool for capturing disease control from the patient's perspective to address these barriers. Methods: Development based on literature review, patient focus groups/interviews and a steering group, defining a limited set of generic questions. The ‘IBD-Control’ questionnaire comprises 13 items plus a visual analogue scale (VAS) (0–100). Prospective validation involved baseline completion of IBD-Control, quality of life (QoL) questionnaire (UK-IBD-Q), EuroQol (EQ-5D), Hospital Anxiety and Depression Score; and clinician assessment (blinded to questionnaire; recording Harvey-Bradshaw Index or Simple Clinical Colitis Activity Index; Global Clinician Rating; treatment outcome). Results: 299 patients returned baseline surveys (Crohn's disease, n=160; ulcerative colitis, n=139) and 138 attended for repeat visits. Completion time (mean; SD): 1 min 15 s; 25 s; Internal consistency: Cronbach's α for all 13 items (0.85); for subgroup of eight questions (‘IBD-Control-8’; 0.86). Strong correlation between IBD-Control-8 and IBD-Control-VAS (r=0.81). Test-retest reliability (2 week repeat): intra-class correlation=0.97 for IBD-Control-8 and 0.96 for IBD-Control-VAS. Construct validity: Moderate-to-strong correlations between IBD-Control-8 and IBD-Control-VAS versus activity indices, UK-IBD-Q and EQ-5D (utility) with r values 0.52–0.86. Discriminant validity (mean instrument scores for remission, mild, moderate or severe): p<0.001 (analysis of variance (ANOVA)). Sensitivity to change: Effect sizes: 0.76–1.44. Conclusions: The IBD-Control is a rapid, reliable, valid and sensitive instrument for measuring overall disease control from the patient's perspective. Unlike existing patient reported outcome measures, its simplicity, ease-of-use and generic applicability make it a candidate for supporting routine care.

Item Type:	Article
Additional Information:	## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords:	IBD Control Collaborative, Humans, Inflammatory Bowel Diseases, Severity of Illness Index, Focus Groups, Linear Models, Prospective Studies, Feasibility Studies, Pilot Projects, Reproducibility of Results, Psychometrics, Qualitative Research, Quality of Life, Adult, Middle Aged, Patient Acceptance of Health Care, Female, Male, Interviews as Topic, Visual Analog Scale, Surveys and Questionnaires, Outcome Assessment, Health Care
Depositing User:	Symplectic Admin
Date Deposited:	27 Mar 2020 09:16
Last Modified:	18 Jan 2023 23:56
DOI:	10.1136/gutjnl-2013-305600
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3080648