Core outcome set for uncomplicated acute appendicitis in children and young people

Sherratt, FC ORCID: 0000-0003-4147-9305, Allin, BSR, Kirkham, JJ, Walker, E, Young, B ORCID: 0000-0001-6041-9901, Wood, W, Beasant, L, Eaton, S and Hall, NJ
(2020) Core outcome set for uncomplicated acute appendicitis in children and young people. BRITISH JOURNAL OF SURGERY, 107 (8). pp. 1013-1022.

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<h4>Background</h4>Research studies to inform clinical practice and policy in children and young people with appendicitis are hampered by inconsistent selection and reporting of outcomes. The aim of this study was to develop a core outcome set for reporting all studies of uncomplicated acute appendicitis in children and young people.<h4>Methods</h4>Systematic literature reviews, qualitative interviews with parents and patients treated for uncomplicated acute appendicitis, and a Study-Specific Advisory Group informed a long list of outcomes. Outcomes were then prioritized by stakeholders based in the UK (patients, parents, and paediatric and general surgeons) in an online three-round Delphi consensus process, followed by face-to-face consensus meetings.<h4>Results</h4>A long list of 40 items was scored by 147 key stakeholders in the first Delphi round, of whom 90 completed the two subsequent Delphi rounds. The final core outcome set comprises 14 outcomes: intra-abdominal abscess, reoperation (including interventional radiology procedure), readmission to hospital, bowel obstruction, wound infection, antibiotic failure, wound complication, negative appendicectomy, recurrent appendicitis, death, patient stress/psychological distress, length of hospital stay, time away from full activity and child's quality of life.<h4>Conclusion</h4>A core outcome set comprising 14 outcomes across five key domains has been developed for reporting studies in children and young people with uncomplicated acute appendicitis. Further work is required to determine how and when to measure these outcomes.

Item Type: Article
Uncontrolled Keywords: Appendicitis Core Outcome Set Study Group, Humans, Appendicitis, Acute Disease, Recurrence, Postoperative Complications, Length of Stay, Appendectomy, Consensus, Delphi Technique, Adolescent, Child, Child, Preschool, Outcome Assessment, Health Care
Depositing User: Symplectic Admin
Date Deposited: 30 Mar 2020 11:11
Last Modified: 18 Jan 2023 23:56
DOI: 10.1002/bjs.11508
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