Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study.



FitzMaurice, Thomas Simon, McNamara, Paul Stephen ORCID: 0000-0002-7055-6034, Nazareth, Dilip ORCID: 0000-0002-6114-0467, McCann, Caroline, Bedi, Ram, Shaw, Matthew ORCID: 0000-0001-9184-5591 and Walshaw, Martin
(2020) Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study. BMJ Open Respir Res, 7 (1).

Access the full-text of this item by clicking on the Open Access link.

Abstract

INTRODUCTION: Dynamic chest radiography (DCR) uses novel, low-dose radiographic technology to capture images of the thoracic cavity while in motion. Pulmonary function testing is important in cystic fibrosis (CF). The tolerability, rapid acquisition and lower radiation and cost compared with CT imaging may make DCR a useful adjunct to current standards of care. METHODS AND ANALYSIS: This is an observational, non-controlled, non-randomised, single-centre, prospective study. This study is conducted at the Liverpool Heart and Chest Hospital (LHCH) adult CF unit. Participants are adults with CF. This study reviews DCR taken during routine CF Annual Review (n=150), validates DCR-derived lung volumes against whole body plethysmography (n=20) and examines DCR at the start and end of pulmonary exacerbations of CF (n=20). The primary objectives of this study are to examine if DCR provides lung function information that correlates with PFT, and lung volumes that correlate whole body plethysmography. ETHICS AND DISSEMINATION: This study has received the following approvals: HRA REC (11 December 2019) and LHCH R&I (11 October 2019). Results are made available to people with CF, the funders and other researchers. Processed, anonymised data are available from the research team on request. TRIAL REGISTRATION NUMBER: ISRCTN 64994816.

Item Type: Article
Uncontrolled Keywords: cystic fibrosis, lung physiology, respiratory infection, respiratory muscles
Depositing User: Symplectic Admin
Date Deposited: 31 Mar 2020 10:16
Last Modified: 02 Oct 2021 00:15
DOI: 10.1136/bmjresp-2020-000569
Open Access URL: http://bmjopenrespres.bmj.com/cgi/content/full/7/1...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3081261