Plasma nucleotide reverse transcriptase inhibitor concentration and their associations with liver and renal parameters in people living with HIV.


Wang, Xinzhu, Boffito, Marta, Dickinson, Laura ORCID: 0000-0001-5557-9396, Bagkeris, Emmanouil, Khoo, Saye, Post, Frank A, Vera, Jaime, Williams, Ian, Ndoutoumou, Amalia, Anderson, Jane et al (show 5 more authors) (2020) Plasma nucleotide reverse transcriptase inhibitor concentration and their associations with liver and renal parameters in people living with HIV. AIDS, 34 (5). pp. 790-793.

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Abstract

: Associations between markers of liver and renal dysfunction and nucleotide reverse transcriptase inhibitor plasma exposure are ill-defined. As part of a large cohort study (Pharmacokinetic and Clinical Observations in People over Fifty), we analysed associations between alanine aminotransferase and estimated glomerular filtration rate results in people living with HIV on tenofovir disoproxil fumarate, emtricitabine, abacavir and lamivudine. While we found no associations between nucleotide reverse transcriptase inhibitor concentrations and alanine aminotransferase, lower estimated glomerular filtration rate values were associated with greater tenofovir, emtricitabine and lamivudine exposure, whereas abacavir showed no associations.

Item Type: Article
Uncontrolled Keywords: POPPY Study, Liver, Kidney, Humans, HIV Infections, Nucleotides, Lamivudine, Drug Combinations, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Treatment Outcome, Viral Load, Cohort Studies, Cross-Sectional Studies, Emtricitabine
Depositing User: Symplectic Admin
Date Deposited: 01 Apr 2020 11:12
Last Modified: 18 Jan 2023 23:56
DOI: 10.1097/QAD.0000000000002479
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3081414
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