Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis



Ray, Stephen, Fuller, Charlotte, Boubour, Alexandra ORCID: 0000-0003-1140-7132, Bonnett, Laura, Seydel, Karl and Griffiths, Michael
(2020) Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis.

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Abstract

Abstract Background: Non-traumatic coma is a common acute childhood presentation to healthcare facilities in Africa and is associated with high morbidity and mortality. Historically, the majority of cases were attributed to cerebral malaria (CM), but with the recent drastic reduction in malaria incidence, non-malarial coma is a larger proportion of cases, and determining the aetiology is diagnostically challenging, particularly in resource-limited settings. The purpose of this paper is to provide a protocol for a systematic review on the aetiology and clinical outcome of non-traumatic coma in African children.Methods: The following databases will be searched: MEDLINE, Embase, and Scopus. Published articles of all languages and publication date on non-traumatic coma in African children will be included. Disease-specific articles will also be included, providing that coma is associated. Two authors will independently assess the studies for risk of bias, following which the data will be analysed, synthesised, and discussed.Discussion: This systematic review will provide a summary of the best available evidence on the aetiology and outcome of non-traumatic coma in African children. This review is registered in PROSPERO International Prospective Register of Systematic Reviews (CRD42020141937).

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 15 Apr 2020 10:11
Last Modified: 29 Sep 2020 09:13
DOI: 10.21203/rs.3.rs-17729/v1
URI: http://livrepository.liverpool.ac.uk/id/eprint/3083160