HDL-apoA-I kinetics in response to 16 wk of exercise training in men with nonalcoholic fatty liver disease

Whyte, Martin B, Shojaee-Moradie, Fariba, Sharaf, Sharaf E, Cuthbertson, Daniel J ORCID: 0000-0002-6128-0822, Kemp, Graham J ORCID: 0000-0002-8324-9666, Barrett, Mark, Jackson, Nicola C, Herring, Roselle A, Wright, John, Thomas, E Louise
et al (show 2 more authors) (2020) HDL-apoA-I kinetics in response to 16 wk of exercise training in men with nonalcoholic fatty liver disease. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 318 (6). E839-E847.

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Nonalcoholic fatty liver disease (NAFLD) is characterized by low-circulating concentration of high-density lipoprotein cholesterol (HDL-C) and raised triacylglycerol (TAG). Exercise reduces hepatic fat content, improves insulin resistance and increases clearance of very-low-density lipoprotein-1 (VLDL<sub>1</sub>). However, the effect of exercise on TAG and HDL-C metabolism is unknown. We randomized male participants to 16 wk of supervised, moderate-intensity aerobic exercise (<i>n</i> = 15), or conventional lifestyle advice (<i>n</i> = 12). Apolipoprotein A-I (apoA-I) and VLDL-TAG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes (1-[<sup>13</sup>C]-leucine and 1,1,2,3,3-<sup>2</sup>H<sub>5</sub> glycerol) pre- and postintervention. Participants underwent MRI/spectroscopy to assess changes in visceral fat. Results are means ± SD. At baseline, there were no differences between exercise and control groups for age (52.4 ± 7.5 vs. 52.8 ± 10.3 yr), body mass index (BMI: 31.6 ± 3.2 vs. 31.7 ± 3.6 kg/m<sup>2</sup>), and waist circumference (109.3 ± 7.5 vs. 110.0 ± 13.6 cm). Percentage of liver fat was 23.8 (interquartile range 9.8-32.5%). Exercise reduced body weight (101.3 ± 10.2 to 97.9 ± 12.2 kg; <i>P</i> < 0.001) and hepatic fat content [from 19.6%, interquartile range (IQR) 14.6-36.1% to 8.9% (4.4-17.8%); <i>P</i> = 0.001] and increased the fraction HDL-C concentration (measured following ultracentrifugation) and apoA-I pool size with no change in the control group. However, plasma and VLDL<sub>1</sub>-TAG concentrations and HDL-apoA-I fractional catabolic rate (FCR) and production rate (PR) did not change significantly with exercise. Both at baseline (all participants) and after exercise there was an inverse correlation between apoA-I pool size and VLDL-TAG and -apoB pool size. The modest effect of exercise on HDL metabolism may be explained by the lack of effect on plasma and VLDL<sub>1</sub>-TAG.

Item Type: Article
Uncontrolled Keywords: exercise, HDL, NALFD
Depositing User: Symplectic Admin
Date Deposited: 24 Apr 2020 14:31
Last Modified: 18 Jan 2023 23:54
DOI: 10.1152/ajpendo.00019.2020
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3084002