m7GHub: deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human



Song, Bowen, Tang, Yujiao, Chen, Kunqi, Wei, Zhen, Rong, Rong, Lu, Zhiliang ORCID: 0000-0002-3442-1415, Su, Jionglong, de Magalhaes, Joao Pedro, Rigden, Daniel J ORCID: 0000-0002-7565-8937 and Meng, Jia ORCID: 0000-0003-3455-205X
(2020) m7GHub: deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human. Bioinformatics, 36 (11). 3528 - 3536.

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Abstract

Motivation Recent progress in N7-methylguanosine (m7G) RNA methylation studies has focused on its internal (rather than capped) presence within mRNAs. Tens of thousands of internal mRNA m7G sites have been identified within mammalian transcriptomes, and a single resource to best share, annotate and analyze the massive m7G data generated recently are sorely needed. Results We report here m7GHub, a comprehensive online platform for deciphering the location, regulation and pathogenesis of internal mRNA m7G. The m7GHub consists of four main components, including: the first internal mRNA m7G database containing 44 058 experimentally validated internal mRNA m7G sites, a sequence-based high-accuracy predictor, the first web server for assessing the impact of mutations on m7G status, and the first database recording 1218 disease-associated genetic mutations that may function through regulation of m7G methylation. Together, m7GHub will serve as a useful resource for research on internal mRNA m7G modification.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 29 Apr 2020 09:57
Last Modified: 25 Jan 2022 19:42
DOI: 10.1093/bioinformatics/btaa178
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3085113