Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis

Qin, Kun, Zhang, Feifei, Chen, Taolin, Li, Lei, Li, Wenbin, Suo, Xueling, Lei, Du, Kemp, Graham J ORCID: 0000-0002-8324-9666 and Gong, Qiyong (2020) Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis. JOURNAL OF BEHAVIORAL ADDICTIONS, 9 (1). pp. 44-57. ISSN 2062-5871, 2063-5303

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Official URL: https://doi.org/10.1556/2006.2020.00006

Abstract

<h4>Background and aims</h4>Numerous studies on behavioral addictions (BAs) have reported gray matter (GM) alterations in multiple brain regions by using voxel-based morphometry (VBM). However, findings are poorly replicated and it remains elusive whether distinct addictive behaviors are underpinned by shared abnormalities. In this meta-analysis, we integrated VBM studies on different BAs to investigate common GM abnormalities in individuals with BAs.<h4>Methods</h4>Numerous studies on behavioral addictions (BAs) have reported gray matter (GM) alterations in multiple brain regions by using voxel-based morphometry (VBM). However, findings are poorly replicated and it remains elusive whether distinct addictive behaviors are underpinned by shared abnormalities. In this meta-analysis, we integrated VBM studies on different BAs to investigate common GM abnormalities in individuals with BAs.<h4>Results</h4>Twenty studies including 505 individuals with BAs and 564 healthy controls met the inclusion criteria. Compared with healthy controls, individuals with BAs showed GM atrophy in the left anterior cingulate (extending to the left medial superior frontal gyrus and bilateral orbitofrontal gyrus), right putamen and right supplementary motor area. Subgroup analysis found heterogeneity in gender and subtypes of BAs. Meta-regression revealed that GM decreases in the left anterior cingulate and right supplementary motor area were positively correlated with addictive severity. Higher impulsivity was associated with smaller volume of the left anterior cingulate.<h4>Discussion and conclusions</h4>Our findings on BAs were mainly derived from internet gaming disorder (IGD) and pathological gambling (PG) studies, preliminarily suggesting that GM atrophy in the prefrontal and striatal areas might be a common structural biomarker of BAs.

Item Type:	Article
Uncontrolled Keywords:	behavioral addictions, magnetic resonance imaging, gray matter, voxel based morphometry, meta-analysis
Depositing User:	Symplectic Admin
Date Deposited:	06 May 2020 15:09
Last Modified:	07 Dec 2024 01:18
DOI:	10.1556/2006.2020.00006
Open Access URL:	https://akjournals.com/view/journals/2006/9/1/arti...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3086228