Batie, Michael 
ORCID: 0000-0002-7508-6641 and Rocha, Sonia
(2020)
Gene transcription and chromatin regulation in hypoxia.
Biochemical Society transactions, 48 (3).
pp. 1121-1128.
Abstract
Oxygen sensing is an essential feature of metazoan biology and reductions in oxygen availability (hypoxia) have both physiological and pathophysiological implications. Co-ordinated mechanisms have evolved for sensing and responding to hypoxia, which involve diverse biological outputs, with the main aim of restoring oxygen homeostasis. This includes a dynamic gene transcriptional response, the central drivers of which are the hypoxia-inducible factor (HIF) family of transcription factors. HIFs are regulated in an oxygen-dependent manner and while their role in hypoxia is well established, it is apparent that other key players are required for gene expression control in hypoxia. In this review, we highlight the current understanding of the known and potential molecular mechanisms underpinning gene transcriptional responses to hypoxia in mammals, with a focus on oxygen-dependent effects on chromatin structure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Chromatin, Hypoxia, Hypoxia-inducible factors, Transcription |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 11 May 2020 10:30 |
| Last Modified: | 18 Jan 2023 23:52 |
| DOI: | 10.1042/bst20191106 |
| Open Access URL: | https://portlandpress.com/biochemsoctrans/article-... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3086504 |
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