White Matter Abnormalities in Anorexia Nervosa: Psychoradiologic Evidence From Meta-Analysis of Diffusion Tensor Imaging Studies Using Tract Based Spatial Statistics



Zhang, Simin, Wang, Weina, Su, Xiaorui, Li, Lei, Yang, Xibiao, Su, Jingkai, Tan, Qiaoyue, Zhao, Youjin, Sun, Huaiqiang, Kemp, Graham J ORCID: 0000-0002-8324-9666
et al (show 2 more authors) (2020) White Matter Abnormalities in Anorexia Nervosa: Psychoradiologic Evidence From Meta-Analysis of Diffusion Tensor Imaging Studies Using Tract Based Spatial Statistics. FRONTIERS IN NEUROSCIENCE, 14. 159-.

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Abstract

Background: Anorexia nervosa (AN) is a debilitating illness whose neural basis remains unclear. Studies using tract-based spatial statistics (TBSS) with diffusion tensor imaging (DTI) have demonstrated differences in white matter (WM) microarchitecture in AN, but the findings are inconclusive and controversial. Objectives: To identify the most consistent WM abnormalities among previous TBSS studies of differences in WM microarchitecture in AN. Methods: By systematically searching online databases, a total of 11 datasets were identified, including 245 patients with AN and 246 healthy controls (HC). We used Seed-based d Mapping to analyze fractional anisotropy (FA) differences between AN patients and HC, and performed meta-regression analysis to explore the effects of clinical characteristics on WM abnormalities in AN. Results: The pooled results of all AN patients showed robustly lower FA in the corpus callosum (CC) and the cingulum compared to HC. These two regions preserved significance in the sensitivity analysis as well as in all subgroup analyses. Fiber tracking showed that the WM tracts primarily involved were the body of the CC and the cingulum bundle. Meta-regression analysis revealed that the body mass index and mean age were not linearly correlated with the lower FA. Conclusions: The most consistent WM microstructural differences in AN were in the interhemispheric connections and limbic association fibers. These common "targets" advance our understanding of the complex neural mechanisms underlying the puzzling symptoms of AN, and may help in developing early treatment approaches.

Item Type: Article
Uncontrolled Keywords: anorexia nervosa, diffusion tensor, tract-based spatial statistics, fractional anisotropy, magnetic resonance imaging, psychoradiology
Depositing User: Symplectic Admin
Date Deposited: 20 May 2020 09:24
Last Modified: 18 Jan 2023 23:51
DOI: 10.3389/fnins.2020.00159
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3088050