COVID-19-Considerations for the paediatric rheumatologist



Hedrich, Christian M ORCID: 0000-0002-1295-6179
(2020) COVID-19-Considerations for the paediatric rheumatologist. CLINICAL IMMUNOLOGY, 214. 108420-.

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Abstract

The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the other hand, can carry and transmit the virus, but usually do not develop severe disease. Mortality in the paediatric age-group is relatively low. Differences in virus containment and clearance, as well as reduced inflammation-related tissue and organ damage may be caused by age-specific environmental and host factors. Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting "cytokine storm" that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications.

Item Type: Article
Uncontrolled Keywords: COVID, SARS, SARS-CoV2, Paediatric, Inflammation, ARDS, Cytokine storm, Rheumatology
Depositing User: Symplectic Admin
Date Deposited: 20 May 2020 09:22
Last Modified: 18 Jan 2023 23:51
DOI: 10.1016/j.clim.2020.108420
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3088135