Hedrich, Christian M ORCID: 0000-0002-1295-6179
(2020)
COVID-19-Considerations for the paediatric rheumatologist.
CLINICAL IMMUNOLOGY, 214.
108420-.
Text
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Abstract
The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions of lifes across the globe. A significant proportion of adult patients require hospitalisation and may develop severe life-threatening complications. Children, on the other hand, can carry and transmit the virus, but usually do not develop severe disease. Mortality in the paediatric age-group is relatively low. Differences in virus containment and clearance, as well as reduced inflammation-related tissue and organ damage may be caused by age-specific environmental and host factors. Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting "cytokine storm" that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications.
Item Type: | Article |
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Uncontrolled Keywords: | COVID, SARS, SARS-CoV2, Paediatric, Inflammation, ARDS, Cytokine storm, Rheumatology |
Depositing User: | Symplectic Admin |
Date Deposited: | 20 May 2020 09:22 |
Last Modified: | 18 Jan 2023 23:51 |
DOI: | 10.1016/j.clim.2020.108420 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3088135 |