Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study



Larivière, Sara, Rodríguez-Cruces, Raúl, Royer, Jessica, Caligiuri, Maria Eugenia, Gambardella, Antonio, Concha, Luis, Keller, Simon, Cendes, Fernando, Yasuda, Clarissa, Bonilha, Leonardo
et al (show 52 more authors) (2020) Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study.

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Abstract

SUMMARY Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1,021 adults with epilepsy compared to 1,564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy co-localized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Indices of progressive atrophy further revealed a strong influence of connectome architecture on disease progression in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients, and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided novel insights into the macroscale features that shape the pathophysiology of common epilepsies.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 27 May 2020 09:16
Last Modified: 29 Sep 2020 08:13
DOI: 10.1101/2020.05.04.076836
URI: http://livrepository.liverpool.ac.uk/id/eprint/3088988