Review article: impact of cigarette smoking on intestinal inflammation-direct and indirect mechanisms

Papoutsopoulou, Stamatia ORCID: 0000-0001-6665-8508, Satsangi, Jack, Campbell, Barry J ORCID: 0000-0002-7407-012X and Probert, Chris S ORCID: 0000-0003-0477-6714 (2020) Review article: impact of cigarette smoking on intestinal inflammation-direct and indirect mechanisms ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 51 (12). pp. 1268-1285. ISSN 0269-2813, 1365-2036

Text Review.pdf - Published version Download (1MB) | Preview

Abstract

Background: The inflammatory bowel diseases, Crohn's disease and ulcerative colitis are related multifactorial diseases. Their pathogenesis is influenced by each individual's immune system, the environmental factors within exposome and genetic predisposition. Smoking habit is the single best-established environmental factor that influences disease phenotype, behaviour and response to therapy. Aim: To assess current epidemiological, experimental and clinical evidence that may explain how smoking impacts on the pathogenesis of inflammatory bowel disease. Methods: A Medline search for 'cigarette smoking', in combination with terms including ‘passive’, ‘second-hand’, 'intestinal inflammation', ‘Crohn's disease’, ‘ulcerative colitis’, 'colitis'; 'intestinal epithelium', ‘immune system', 'intestinal microbiota', ‘tight junctions’, ‘mucus’, ‘goblet cells’, ‘Paneth cells’, ‘autophagy’; ‘epigenetics’, ‘genes’, ‘DNA methylation’, ‘histones’, ‘short noncoding/long noncoding RNAs’; ‘carbon monoxide/CO’ and ‘nitric oxide/NO’ was performed. Results: Studies found evidence of direct and indirect effects of smoking on various parameters, including oxidative damage, impairment of intestinal barrier and immune cell function, epigenetic and microbiota composition changes, that contribute to the pathogenesis of inflammatory bowel disease. Conclusions: Cigarette smoking promotes intestinal inflammation by affecting the function and interactions among intestinal epithelium, immune system and microbiota/microbiome.

Item Type:	Article
Uncontrolled Keywords:	Intestines, Humans, Colitis, Ulcerative, Enteritis, Inflammatory Bowel Diseases, Crohn Disease, Risk Factors, Signal Transduction, Cigarette Smoking
Depositing User:	Symplectic Admin
Date Deposited:	03 Jun 2020 08:46
Last Modified:	16 Jun 2026 07:27
DOI:	10.1111/apt.15774
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3089344
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.