Development of the Cauda Equina Syndrome Core Outcome Set for research studies

Srikandarajah, Nisaharan (2020) Development of the Cauda Equina Syndrome Core Outcome Set for research studies. PhD thesis, University of Liverpool.

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	Text Srikandarajah N, Wilby M, Clark S, Noble A, Williamson P, Marson T. Outcomes reported after surgery for cauda equina syndrome a systematic literature review. Spine. 2018 Sep 1;43(17)E1005..pdf - Unspecified Download (827kB) | Preview
	Text Srikandarajah N, Noble AJ, Wilby M, Clark S, Williamson PR, Marson AG. Protocol for the development of a core outcome set for cauda equina syndrome systematic literature review, qualitative interviews, Del.pdf - Unspecified Download (527kB) | Preview
	Text Srikandarajah N, Noble A, Clark S, Wilby M, Freeman BJ, Fehlings MG, Williamson PR, Marson T. Cauda Equina Syndrome Core Outcome Set (CESCOS) An international patient and healthcare professional consensus.pdf - Unspecified Download (629kB) | Preview

Abstract

Chapter 1: Cauda Equina Syndrome (CES) is an emergency condition that requires acute intervention and can lead to permanent neurological deficit in working age adults. A Core Outcome Set (COS) is the minimum set of outcomes that should be reported in any future research study within a specific disease area. A COS for patients with CES will be developed for use in future research studies. Chapter 2&3: A systematic literature review (SLR) was performed using PRISMA guidelines to document the outcomes used in CES studies. A total of 1873 studies were identified of which 61 met the inclusion criteria. There were 737 verbatim outcome terms reported. There was significant heterogeneity in the outcomes reported for studies after surgery for CES patients. The duration from the start of the CES to the operation was also analysed in these studies. There was significant heterogeneity in the reporting and definition of the timing to intervention in CES. Chapter 4: The outcomes of importance to patients and the lived experience of CES considering its severity was elicited through semi structured qualitative interviews. A sampling frame was used, interviews were consented for, audio recorded and transcribed for thematic ... (continues)

Item Type:	Thesis (PhD)
Divisions:	Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine
Depositing User:	Symplectic Admin
Date Deposited:	14 Aug 2020 08:56
Last Modified:	26 Oct 2024 21:59
DOI:	10.17638/03090798
Supervisors:	Marson, Anthony Noble, Adam ORCID: 0000-0002-8070-4352 Williamson, Paula ORCID: 0000-0001-9802-6636 Clark, Simon Wilby, Martin
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3090798