TNFSF14/LIGHT, a Non-Canonical NF-kB Stimulus, Induces the HIF Pathway



D'Ignazio, Laura, Batie, Michael and Rocha, Sonia ORCID: 0000-0002-2413-4981
(2018) TNFSF14/LIGHT, a Non-Canonical NF-kB Stimulus, Induces the HIF Pathway. Cells.

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Abstract

Non-canonical NF-kB signalling plays important roles in development and function of the immune system but also is deregulated in a number of inflammatory diseases. Although, NF-kB and HIF crosstalk has been documented, this has only been described following canonical NF-kB stimulation, involving RelA/p50 and the HIF-1 dimer. Here we report that the non-canonical inducer TNFSF14/LIGHT leads to HIF induction and activation in cancer cells. We demonstrate that only HIF-2a is induced at the transcriptional level following non-canonical NF-kB activation, via a mechanism dependent on the p52 subunit. Furthermore, we demonstrate that p52 can bind to the HIF-2a gene in cells. These results indicate that non-canonical NF-kB can lead to HIF signalling implicating HIF-2a as one of the downstream effectors of this pathway in cells.

Item Type: Article
Uncontrolled Keywords: Cancer, 1 Underpinning research, 1.1 Normal biological development and functioning, Cancer
Depositing User: Symplectic Admin
Date Deposited: 22 Jun 2020 08:57
Last Modified: 15 Mar 2024 14:04
DOI: 10.20944/preprints201807.0007.v1
Open Access URL: https://www.mdpi.com/2073-4409/7/8/102
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3091014