Infectious Etiologies of Intussusception Among Children <2 Years Old in 4 Asian Countries

Burnett, Eleanor, Kabir, Furqan, Nguyen, Van Trang, Rayamajhi, Ajit, Satter, Syed M, Liu, Jie, Yousafzai, Mohammad Tahir, Dang, Duc Anh, Basnet, Anupama Thapa, Flora, Meerjady S
et al (show 13 more authors) (2020) Infectious Etiologies of Intussusception Among Children <2 Years Old in 4 Asian Countries. JOURNAL OF INFECTIOUS DISEASES, 221 (9). pp. 1499-1505.

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<h4>Background</h4>The etiology of intussusception, the leading cause of bowel obstruction in infants, is unknown in most cases. Adenovirus has been associated with intussusception and slightly increased risk of intussusception with rotavirus vaccination has been found. We conducted a case-control study among children <2 years old in Bangladesh, Nepal, Pakistan, and Vietnam to evaluate infectious etiologies of intussusception before rotavirus vaccine introduction.<h4>Methods</h4>From 2015 to 2017, we enrolled 1-to-1 matched intussusception cases and hospital controls; 249 pairs were included. Stool specimens were tested for 37 infectious agents using TaqMan Array technology. We used conditional logistic regression to estimate odds ratio (OR) and 95% confidence interval (CI) of each pathogen associated with intussusception in a pooled analysis and quantitative subanalyses.<h4>Results</h4>Adenovirus (OR, 2.67; 95% CI, 1.75-4.36) and human herpes virus 6 (OR, 3.50; 95% CI, 1.15-10.63) were detected more frequently in cases than controls. Adenovirus C detection <20 quantification cycles was associated with intussusception (OR, 18.59; 95% CI, 2.45-140.89). Wild-type rotavirus was not associated with intussusception (OR, 1.07; 95% CI, 0.52-2.22).<h4>Conclusions</h4>In this comprehensive evaluation, adenovirus and HHV-6 were associated with intussusception. Future research is needed to better understand mechanisms leading to intussusception, particularly after rotavirus vaccination.

Item Type: Article
Uncontrolled Keywords: adenovirus, rotavirus, intussusception, intestinal obstruction, viral pathogens
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 26 May 2021 15:17
Last Modified: 10 Oct 2023 05:04
DOI: 10.1093/infdis/jiz621
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