Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease

Hinton, Jay ORCID: 0000-0003-2671-6026, Zhu, X, Owen, sian, Gordon, melita ORCID: 0000-0002-0629-0884 and Canals Alvarez, Rocio (2020) Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease. Proceedings of the National Academy of Sciences of USA, 117 (34). pp. 20717-20728.

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Abstract

Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defense. However, proposed protective roles of MAIT cells in human infections remain unproven and clinical conditions associated with selective absence of MAIT cells have not been identified. We report that typhoidal and nontyphoidal Salmonella enterica strains activate MAIT cells. However, S. Typhimurium sequence type 313 (ST313) lineage 2 strains, which are responsible for the burden of multidrug-resistant nontyphoidal invasive disease in Africa, escape MAIT cell recognition through overexpression of ribB. This bacterial gene encodes the 4-dihydroxy-2-butanone-4-phosphate synthase enzyme of the riboflavin biosynthetic pathway. The MAIT cell-specific phenotype did not extend to other innate lymphocytes. We propose that ribB overexpression is an evolved trait that facilitates evasion from immune recognition by MAIT cells and contributes to the invasive pathogenesis of S. Typhimurium ST313 lineage 2.

Item Type:	Article
Uncontrolled Keywords:	Salmonella Typhimurium, sequence type 313, ST313, invasive nontyphoidal Salmonella, MR1
Depositing User:	Symplectic Admin
Date Deposited:	30 Jul 2020 15:11
Last Modified:	18 Jan 2023 23:46
DOI:	10.1073/pnas.2007472117
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3093123

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• Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease. (deposited 07 Jul 2020 07:46)
  • Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease. (deposited 30 Jul 2020 15:11) [Currently Displayed]