Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease



Hinton, Jay ORCID: 0000-0003-2671-6026, Zhu, X, Owen, sian, Gordon, melita ORCID: 0000-0002-0629-0884 and Canals Alvarez, Rocio
(2020) Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease. Proceedings of the National Academy of Sciences of USA, 117 (34). 20717 - 20728.

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Abstract

Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defense. However, proposed protective roles of MAIT cells in human infections remain unproven and clinical conditions associated with selective absence of MAIT cells have not been identified. We report that typhoidal and nontyphoidal Salmonella enterica strains activate MAIT cells. However, S. Typhimurium sequence type 313 (ST313) lineage 2 strains, which are responsible for the burden of multidrug-resistant nontyphoidal invasive disease in Africa, escape MAIT cell recognition through overexpression of ribB. This bacterial gene encodes the 4-dihydroxy-2-butanone-4-phosphate synthase enzyme of the riboflavin biosynthetic pathway. The MAIT cell-specific phenotype did not extend to other innate lymphocytes. We propose that ribB overexpression is an evolved trait that facilitates evasion from immune recognition by MAIT cells and contributes to the invasive pathogenesis of S. Typhimurium ST313 lineage 2.

Item Type: Article
Depositing User: Symplectic Admin
Date Deposited: 30 Jul 2020 15:11
Last Modified: 08 Jun 2021 11:42
DOI: 10.1073/pnas.2007472117
URI: https://livrepository.liverpool.ac.uk/id/eprint/3093123

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