Base excision repair and its implications to cancer therapy

Grundy, Gabrielle J ORCID: 0000-0003-1506-3664 and Parsons, Jason L ORCID: 0000-0002-5052-1125 (2020) Base excision repair and its implications to cancer therapy. GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR, 64 (5). pp. 831-843.

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Abstract

Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular oxidative stress and in response to exogenous insults. The pathway is a coordinated, sequential process involving 30 proteins or more in which single strand breaks are generated as intermediates during the repair process. While deficiencies in BER activity can lead to high mutation rates and tumorigenesis, cancer cells often rely on increased BER activity to tolerate oxidative stress. Targeting BER has been an attractive strategy to overwhelm cancer cells with DNA damage, improve the efficacy of radiotherapy and/or chemotherapy, or form part of a lethal combination with a cancer specific mutation/loss of function. We provide an update on the progress of inhibitors to enzymes involved in BER, and some of the challenges faced with targeting the BER pathway.

Item Type:	Article
Uncontrolled Keywords:	Humans, Neoplasms, DNA Repair, Oxidative Stress
Depositing User:	Symplectic Admin
Date Deposited:	14 Jul 2020 09:04
Last Modified:	18 Jan 2023 23:46
DOI:	10.1042/EBC20200013
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3093824